Flowrence®

Helping the leading catalyst suppliers and research institutes developing better and more efficient catalysts with the world's best high throughput technology
Our technologyContact us

Systems Installed

Years of Innovation

Proven Applications

Patents

Highest Data Quality

Reproducible results with accurate microfluidics  distribution. Large isothermal zone with perfect catalyst-feed contacting.

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Unmatched Accuracy

Multi-parallel reactors systems that generate accurate data with outstanding reactor-to-reactor repeatability.
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Proven Applications

Proven Flowrence® technology broadly used with multiple applications thanks to decades of research and development.

Safe to Operate

Inherently safe small-scale reactor technology with minimal chemicals hold up with very fast flushing times. Easy to operate <1 FTE required.

Validated by Customers

Flowrence® technology extensively used by catalyst suppliers and research institutes to accelerate their catalyst R&D.

Fast Screening

Reduced time-to-market with high throughput testing for process optimization and catalyst screening.

Lower Costs

Lower Total Cost of Ownership with small scale testing compared with large scale. Achieve important cost savings per experiment.

Small Footprint

Smallest footprint in the market with low infrastructure costs. Increase the number of reactors in your lab with minimal space required.

We provide our customers the world's most high throughput technology powered by decades of research

Flowrence® Products

4 Reactors

Avantium’s most flexible and easy to use system with a broad number of proven applications. Designed for early-stage catalyst R&D.

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16 Reactors

Our most accurate system with a broad operating window. Designed for fast catalyst screening with outstanding repeatability and reproducibility.

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16 Reactors

Our most advanced system combining all technology of the Flowrence® XR with independent control per reactor for kinetic studies and process design.

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4 Reactors

This system was purposely designed for benchmarking of commercial catalysts.

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Key features of the Flowrence® technology 

Microfluidics distribution

Single glass chip for 16-reactors with 0.5% RSD, offers unmatched reactor-to-reactor repeatability. Easy exchange for different operating conditions.

Tiny-Pressure

Modular, compact, and easy exchange of glass-chips, with integrated pressure indicators.

Tube-in-tube reactor

Easy and quick reactor exchange system. Possibility to use quartz reactors at high pressure.

EasyLoad®

Unique and easy-to-use reactor closing system.  “Ready-to-go” approach without leak testing required.

Full particles and powder loading

No dead-zones, no bed packing or distribution effects. No variability in reactor loading. Small volumes, no compromises.

FlowPro Software

Software purposely build for high throughput systems. Full integration of online and offline data.

Reactor pressure control

The most accurate and stable pressure regulator for 16-reactors, just ±0.5bar RSD.

Active liquid distribution

The most accurate liquid distribution for 16 reactors with active control. Reactor-to-reactor 0.5% RSD.

Individual temperature control

Flexibility in test design with independent Reactor Temperature Control (iRTC).

Automated liquid sampling

Programmable, fully automated liquid product sampling robot for 24/7 hands-off operation.

Proven applications with the Flowrence®

Discover how our customers are leveraging Artificial Intelligence with the Flowrence®

Argonne National Lab 16-reactors Flowrence® XR

Avantium’s 16-reactor fixed bed Flowrence® XR unit was used to study the deposition of 23 different metallic precursors for propyne dimerization to hexadienes in a high-throughput data-driven campaign. A combination of high throughput experiments with computational and machine learning approaches were imperative to finding optimized reaction conditions.

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Recent case studies

Reactor-to-reactor repeatability

An important quality criteria in parallelized reactors systems is reactor-to-reactor repeatability. A good repeatability is achieved when reactors loaded with the same catalyst system yield the same results. This means that the test results and the differences (in...

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Optimizing analytics for improved data quality

Analytics are an integral part of our Flowrence® high-throughput technology, and they play a crucial role in ensuring the quality of experimental data. At Avantium R&D Solutions, we believe that the analytic solutions used to acquire data should be optimized for...

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See what our customers are saying

Argonne
Avantium’s 16-reactor fixed bed Flowrence ® XR unit was used to study the deposition of 23 different metallic precursors for propyne dimerization to hexadienes in a high-throughput data-driven campaign. “It is clear that the improved activity obtained in this...
Read More
Avantium’s 16-reactor fixed bed Flowrence® XR unit was used to study the deposition of 23 different metallic precursors for propyne dimerization to hexadienes in a high-throughput data-driven campaign. “It is clear that the improved activity obtained in this synergistic study could not have been discovered a priori; the high-throughput approach was critical to finding the precise experimental and synthetic conditions at which the catalysts showed meaningful selectivity and conversion to hexadiene.”
Kiel Testimonial
We are now welcoming Avantium’s high-throughput reaction screening platform. We will use the Flowrence ® XD to test our synthesized catalysts for the direct conversion of CO/CO2 to form basic chemicals, for methanol reforming, and for...
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We are now welcoming Avantium’s high-throughput reaction screening platform. We will use the Flowrence ® XD to test our synthesized catalysts for the direct conversion of CO/CO2 to form basic chemicals, for methanol reforming, and for studying ammonia synthesis, all reactions which are crucial to the energy and feedstock transitions.
KAUST Testimonial
These new Flowrence systems strengthen our high-throughput facilities for heterogeneous catalysis and make sure that our researchers keep having access to state of the art technology. We have an excellent experience with Avantium’s equipment and technical support and...
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These new Flowrence systems strengthen our high-throughput facilities for heterogeneous catalysis and make sure that our researchers keep having access to state of the art technology. We have an excellent experience with Avantium’s equipment and technical support and look forward to developing new catalysts by making use of these systems.
BP Testimonial
BP has worked with Avantium in the areas of catalyst discovery and process scoping . The BP and Avantium technology teams collaborated closely in a flexible relationship that was able to exploit the strengths of each company. Our collaborations...
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BP has worked with Avantium in the areas of catalyst discovery and process scoping. The BP and Avantium technology teams collaborated closely in a flexible relationship that was able to exploit the strengths of each company. Our collaborations with Avantium were both fruitful and enjoyable. One way to think of what Avantium does is looking for a needle in a haystack with high-throughput as the metal detector.
IFPEN Testimonial
IFPEN has carefully evaluated the market for advanced technologies in the field of catalytic research and has decided for Avantium's Flowrence ® technology . It is Avantium's advanced technology combined with their application knowledge that made us decide to collaborate...
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IFPEN has carefully evaluated the market for advanced technologies in the field of catalytic research and has decided for Avantium's Flowrence® technology. It is Avantium's advanced technology combined with their application knowledge that made us decide to collaborate with Avantium on a strategic basis. The Flowrence units have allowed us to increase our testing capacity by a factor of 4 whilst reducing our operational costs. We recommend the Flowrence technology for the screening and the ranking of catalysts and remain at your disposal to share our experience with Avantium.
Shell Testimonial
Avantium’s high throughput experimentation technology has been of significant importance to the success of our catalyst development program. This strategic relationship ensures rapid knowledge transfer which brings the new leading-edge products quicker to market, to the benefit of...
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Avantium’s high throughput experimentation technology has been of significant importance to the success of our catalyst development program. This strategic relationship ensures rapid knowledge transfer which brings the new leading-edge products quicker to market, to the benefit of our clients; a key performance indicator for both CRI and Avantium.

We serve a portfolio of global clients

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Flowrence® products specifications

Reactor Section

Easy and quick reactor exchange system. Possibility to use quartz reactors at high pressure.

1 block of 4 reactors

HT = High Temperature max. 800°C nominal, limited to 925°C (<0.5°C reactor to reactor deviation)

4 blocks of 4 reactors

HT  or MT = Medium Temperature max. 525°C (<0.5°C block-to-block deviation)

16 reactors with iRTC

individual Reactor Temperature Control
max. 550°C (<0.5°C reactor-to-reactor)

4 reactors with iRTC

individual Reactor Temperature Control
max. 550°C (<0.5°C reactor-to-reactor)

Temperature Ranges (°C)

100 – 800°C
up 925°C (Option)

50 – 525°C
100 – 800°C
up 925°C (Option)

50 – 550°C

50 – 550°C

Reactor Types

L= Length
OD= Outer Diameter
ID= Inner Diameter
SS= Stainless Steel (< 550⁰C)
Qz= Quartz (< 925⁰C)

L 300 mm 561 mm
OD 3 mm 6 mm
ID SS 2 / 2.6 mm 2 / 3 / 4 / 5 mm
ID Qz 2 mm 2 / 4 mm
300 mm 561 mm 561 mm
3 mm 3 mm 6 mm
2 / 2.6 mm 2 / 2.6 mm 2 / 3 / 4 / 5 mm
2 mm 2 mm 2 / 4 mm
561 mm
3 mm
2 / 2.6 mm
2 mm
561 mm
3 mm
2 / 2.6 mm
2 mm

Maximum Catalyst Bed Length

(isothermal zone tolerance ± 1°C)
Note: isothermal length is dependent on the temperature range

300 / 3 HT 561 / 6 HT
>120 mm @ 450°C >200 mm @ 500°C
>90 mm @ 800°C >150 mm @ 800°C
>140 mm @ 925°C
300 / 3 HT 561 / 3 MT 561 / 6 HT
>120 mm @ 450°C >310 mm @ 450°C >200 mm @ 500°C
>90 mm @ 800°C >150 mm @ 800°C
>140 mm @ 925°C
561 / 3 MT iRTC
250°C ±0.5°C 41cm (4reactors)
350°C±0.5°C 38cm (4reactors)
550°C±0.5°C 28cm (4reactors)
3 reactors at 550°C, 1 reactor 350°C:
550°C=27cm 350°C=41cm ±0.5°C
561 / 3 MT iRTC
250°C ±0.5°C 41cm (4reactors)
350°C±0.5°C 38cm (4reactors)
550°C±0.5°C 28cm (4reactors)
3 reactors at 550°C, 1 reactor 350°C:
550°C=27cm 350°C=41cm ±0.5°C

Catalyst Volume (mL)

(isothermal zone)

0.2 - 0.6 mL 0.4 - 2.0 mL
0.2 - 0.6 mL 0.4 - 1.0 mL 0.4 - 2.0 mL
0.4 - 1.0 mL
0.4 - 1.0 mL

Pressure Ranges (barg)

2 – 80 barg
0.5 – 180 barg (option)

2 – 100 barg
0.5 – 180 barg

2 – 80 barg
0.5 – 180 barg

2 – 20 barg
2 – 50 barg (option)

Reactor Pressure Control

Advanced control RSD ±0.1 barg at reference conditions (gas phase only and 20 barg). For trickle flow Advanced control RSD ±0.5barg.

Standard (±0.5 barg)
Advanced (±0.1 barg) (option)

Standard (±0.5 barg)
Advanced (±0.1 barg) (option)

Advanced (±0.1 barg)

Advanced (±0.1 barg)

Gas Feed Lines

(#Gas Feeds)

Up to 6 + Diluent gas

He, Ar, N2, H2, CH4, CO2, C2H4, C2H6, O2/Inert (≤5%), CO, Other gases

Up to 7 + Diluent gas

He, Ar, N2, H2, CH4, CO2, C2H4, C2H6, O2/Inert (≤5%), CO, Other gases

Up to 7 + Diluent gas

He, Ar, N2, H2, CH4, CO2, C2H4, C2H6, O2/Inert (≤5%), CO, Other gases

Up to 6 + Diluent gas

He, Ar, N2, H2, CH4, CO2, C2H4, C2H6, O2/Inert (≤5%), CO, Other gases

Online Analysis

Full integration GC, MS , GC/MS with data visualisation (option)

Full integration GC, MS , GC/MS with data visualisation

Full integration GC, MS , GC/MS with data visualisation

Full integration GC, MS , GC/MS with data visualisation

Liquid Feed

 Split feeding 8 + 8 reators (option)

Pump-Coriolis dosing system
(ambient, cooled)

Pump-Coriolis dosing system
(ambient, cooled, heated 80°C)

Pump-Coriolis dosing system
(ambient, cooled, heated 80°C)

Pump-Coriolis dosing system
(ambient, cooled, heated 80°C)

Liquid Distribution

Microfluidic Distribution
(4-channel glass-chip)

Microfluidics Distribution
(4x4-channel glass-chip)
(16-channel glass-chip)
Active Liquid Distribution (option)
(with automatic isolation valves)

Active Liquid Distribution
(with automatic isolation valves)

Microfluidic Distribution
(4-channel glass-chip)

Liquid Sampling

(G/L Separation)

Parallel liquid sampling (4 x 20ml vials) with sequential on-line gas phase sampling (option)

Automated liquid sampling (4 rows x 16 vials x 8ml) with sequential on-line gas phase sampling (option)

Automated liquid sampling (4 rows x 16 vials x 8ml) with sequential on-line gas phase sampling (option)

Parallel liquid sampling (4 x 20ml vials) with sequential on-line gas phase sampling (option)

Reactors Effluent Handling

(Off-line Analysis Connection)

Full heated circuit up to 180°C with sequential on-line full gas phase sampling (option)

Full heated circuit up to 200°C with sequential on-line full gas phase sampling

Full heated circuit up to 200°C with sequential on-line full gas phase sampling

Full heated circuit up to 200°C with sequential on-line full gas phase sampling

Offline Analysis

Integrated Workflow: SimDist, total S/N, liquid density, balance, label printer, barcode (option)

Integrated Workflow: SimDist, total S/N, liquid density, balance, label printer, barcode

Integrated Workflow: SimDist, total S/N, liquid density, balance, label printer, barcode

Integrated Workflow: SimDist, total S/N, liquid density, balance, label printer, barcode

Waste Handling

Ambient temperature
Heated wax trapping (option)

Ambient temperature / Cooled containers / Heated compartment (wax trapping, heavies)

Ambient temperature / Cooled containers / Heated compartment (wax trapping, heavies)

Ambient temperature / Cooled containers / Heated compartment (wax trapping, heavies)

Safety

Gas sensors and control box (CO, LEL, VOC)

Gas sensors and control box (CO, LEL, VOC)

Gas sensors and control box (CO, LEL, VOC)

Gas sensors and control box (CO, LEL, VOC)

Flowrence® Software

Flowrence® recipe builder, control & database builder

Flowrence® recipe builder, control & database builder

Flowrence® recipe builder, control & database builder

Flowrence® recipe builder, control & database builder

Microfluidics modular gas distribution

Unrivalled accuracy in gas distribution with patented glass-chips for 4 and 16 reactors, with a guaranteed flow distribution of 0.5% RSD. Quick exchange of glass-chips for different operating conditions. Flexibility to cover a wide range of applications.

TinyPressure glass-chip holder with integrated pressure measurement

Compact modular design for gas and liquid distribution. No high-temperature pressure sensors required. Quick exchange of the microfluidic glass-chips, without the need for time-consuming leak testing.

Tube-in-tube reactor technology with effluent dilution

Unique tube-in-tube design with easy and rapid exchange of the reactor tubes (within minutes!). No need for any connections. Use of inert diluent gas (outside of reactor) to maintain the pressure prevents dead volumes and back flow. Possibility to use quartz reactors at high pressure applications.

Automated liquid sampling system

Programmable, fully automated liquid product sampling robot for 24/7 hands-off operation. Robot equipped with a compact manifold aiming at depressurizing the effluent immediately after each reactor to atmospheric pressure. Eliminates the use of high pressure valves.

Reactor Pressure Control (RPC)

The most accurate and stable pressure regulator for a 16-parallel reactors with just ±0.1bar RSD. The RPC uses microfluidics technology to regulate the pressure of each reactor, maintaining equal distribution of the inlet flow over the 16 reactors.